Hyperoxia and Inhaled NO: Evidence for Extracellular Matrix Damage† 1646

A no-no for NonO and JNK in extracellular matrix homeostasis and vascular stability.

The pivotal role of chronic inflammation in the pathogenesis of atherosclerosis and aortic aneurysm is now firmly established.1 Atherosclerotic lesions usually develop at branch points in arteries with abnormal shear stress. Risk factors such as hypercholesterolemia, hypertension, and cigarette smoke, among others, promote injury to the vascular endothelium, resulting in the infiltration of leu...

Editorial: Brain Extracellular Space: Geometry, Matrix and Physiological Importance

Inhaled NO and pulmonary vasodilation.

To the Editor: Hare et al concluded that inhaled nitric oxide (NO) caused selective pulmonary vasodilation in patients receiving left ventricular assist device support and that this accounted for the increase in mean left atrial pressure, which they considered a beneficial hemodynamic effect. The evidence for pulmonary vasodilation was that pulmonary vascular resistance (PVR) decreased. However...

Marcello Malpighi (1646-1694)

Malpighi was born in 1628 in Crevalcore, Bologna, Italy, and he was baptized 10 March of that year. His parents were Maria Cremonini and Marcantonio Malpighi. He entered the University of Bologna [5] in Bologna in 1646, and his tutor Francesco Natali encouraged him to study medicine, which he began in 1649. While in medical school he was one of only a few students permitted to attend vivisectio...

Dmd058461 1646..1655

A previously developed physiologically based pharmacokinetic model for hepatic transporter substrates was extended to an organic anion transporting polypeptide substrate, telmisartan. Predictions used in vitro data from sandwich culture human hepatocyte and human liver microsome assays. We have developed a novel method to calibrate partition coefficients (Kps) between nonliver tissues and plasm...